منابع مشابه
15 Years of Neuron Cell Biology
the impact of molecular biology in neuronal cell biology has been steadily growing in the past couple of decades and is now an indispensable tool that is available to any Introduction A lot has happened in the world since the first issue of interested investigator. The ability to clone, express, and mutate specific proteins in neurons is the bread-and-Neuron hit the newsstands in March, 1988. A...
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I 1 Summary During this thesis, several novel aspects of TGFβ in human CD4 + T cell biology were investigated. First, we were interested, which factors control the resting state of CD4 + T cells. Genome-wide transcriptional analysis of serum-deprived CD4 + T cells revealed TGFβ to be the most prominent factor controlling the homeostasis of CD4 + T cells. Furthermore, we could show that TGFβ is ...
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The basic components of the plant cell cycle are G1 (postmitotic interphase), S-phase (DNA synthesis phase), G2 (premitotic interphase) and mitosis/cytokinesis. Proliferating cells are phosphoregulated by cyclin-dependent protein kinases (CDKs). Plant D-type cyclins are sensors of the G0 to G1 transition, and are also important for G2/M. At G1/S, the S-phase transcription factor, E2F, is releas...
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The microenvironment of a tumor is known to influence tumor progression and spread to distant sites (metastasis). Padua et al. (2008) now show that transient exposure of breast cancer cells to the signaling molecule transforming growth factor beta (TGFbeta) promotes their extravasation from blood vessels and entry into the lung by upregulation of the adipokine angiopoietin-like 4 (ANGPTL4). The...
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ژورنال
عنوان ژورنال: Journal of Mammary Gland Biology and Neoplasia
سال: 2011
ISSN: 1083-3021,1573-7039
DOI: 10.1007/s10911-011-9220-6